Phagocytosis: Dynamin's Dual Role in Phagosome Biogenesis

Phagocytosis: Dynamin's Dual Role in Phagosome Biogenesis

Dynamins have a well-established role in the fission of vesicles at sites of endocytosis. In phagocytosis, however, a role for certain dynamin isoforms has been reported in the full extension of pseudopods during phagosome formation, not in fission of the phagocytic vacuole. Recent studies in Caenorhabditis elegans have now uncovered a new function of dynamin in phagosome maturation.

Determinants of Phagocytosis, Phagosome Biogenesis and Autophagy for Mycobacterium tuberculosis

Mycobacterium tuberculosis is an intracellular pathogen of mononuclear phagocytes and is highly adapted to the human host. This bacterium enters macrophages by the phagocytic process using a defined subset of receptors and subsequently multiplies within a unique phagosomal compartment. M. tuberculosis has developed multiple strategies to circumvent the normal fate of ingested pathogens both dur...

Phagocytosis and Phagosome Acidification

Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest

Phagosomal biogenesis is a fundamental biological process of particular significance for the function of phagocytic and antigen-presenting cells. The precise mechanisms governing maturation of phagosomes into phagolysosomes are not completely understood. Here, we applied the property of pathogenic mycobacteria to cause phagosome maturation arrest in infected macrophages as a tool to dissect cri...

Phagocytosis: How the Phagosome Became the Phag-ER-some

Phagocytosis is a fundamental mechanism for engulfment of pathogens, dead and dying host cells and other particulate material. Surprisingly, the involvement of the endoplasmic reticulum in macrophage-mediated phagocytosis has only just been discovered.